Abstract
The study purpose: systematization of research results on the production technology and properties of triclabendazole (TCB)-based solid dispersions and polymer substances. Research results: we performed the analysis of technology features for producing solid dispersions (SDs) of the TCB substance with various polymeric substances (polyvinylpyrrolidone, hydroxyethyl starch, pectins, arabinogalactan, etc.), physicochemical properties of the obtained SDs (solubility, TCB preservation and release in model systems), toxicity, and biological activity. HPLC and UV spectroscopy methods were used to study the TCB solubility, preservation, and release from SDs. The solubility rate was taken as an optimization parameter according to which Triclafascid was selected in the form of a SD in the formulation TCB:AG (1:9) for its further introduction into veterinary practice. We studied parameters of the toxicity and antifasciloid effect, process performance, and other parameters as required to introduce Triclafascid. To improve the solubility of Triclafascid, an alternative approach was used to obtain its salt forms by including succinic acid in its formulation. The resulting SDs had significantly higher solubility and efficacy parameters when the TCB dosage was reduced. A series of studies was conducted to develop laboratory regulations and pilot production regulations for introducing Triclafascid into veterinary practice. Conclusions: the systematization of the obtained data on formulation, and on studying physical, chemical, technological, and biological properties made it possible to determine measures to introduce Triclafascid into veterinary practice.
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