Supramolecular complexes of drugs for parasitic sheep invasions

Abstract

The complex of multicellular parasites of sheep in Gorny Altai is mainly represented by intestinal and pulmonary strongilates, moniesia, dikrocelia and parasitic insects, which involves the use of complex parasiticidal agents of a wide spectrum of activity in the system to minimize the volume and frequency of use of drugs. Ivermectin (IVM) has a nematodocidal and entomocidal effect, fenbendazole (FBD) is an effective nematodocide and cestodocide, triclabendazole (TBD) is a recognized trematodocide. To obtain more effective drugs based on these substances, their mechanochemical modification using polyvinylpyrrolidone (PVP) is proposed. The aim of the work is to show the promise of using mechanochemical technology to improve the physicochemical and biological properties of drug substances and to evaluate the effectiveness of compositions of supramolecular complexes ofpolyvinylpyrrolidone with IVM, FBD and TBD in parasitic sheep infestations. Experiments on the study of the parasitocidal activity of compositions for intestinal helminthiases were carried out on a flock of spontaneously invasive sheep in the Shebalinsky district of the Altai Republic. According to the principle of analogues, 6 experimental (10 animals each) and 2 control (20 animals each) groups were formed. The preparations were given to the sheep individually in the form of an aqueous suspension orally. The study demonstrated the high efficiency of solid dispersion (SD) of the composition FBD / IVM / PVP at a dose of FBD - 3.0, IVM – 0.2 mg / kg b / w when administered orally against gastrointestinal strongylates and moniesia (95.8 and 100% ) and a bloodsucker in sheep (92.5%). SD of the composition TBD / IVM / PVP at a dose of TBD - 3.0, IVM - 0.2 showed high efficacy against gastrointestinal strongylates and dicrocelia (96.8 and 100%) and was not effective against moniesia and sheep blood suckers. The initial substances of FBD and TBD showed significantly less activity during parasitic infestations of sheep. The use of the studied SD suggests the possibility of a significant (three-fold) reduction in the dosage of FBD and TBD without loss of parasiticidal activity.