Abstract
AbstractThe study aimed to investigate the therapeutic efficacy of S. dulcamara extract (SDE) in managing type II diabetes‐related parameters, including blood glucose levels, α‐amylase activity, and modulation of endogenous antioxidant enzymes (SOD, GPx, CAT). Diabetes was induced in rats using streptozocin, and the anti‐diabetics effect was evaluated by the administration of S. dulcamara extract at different doses. Blood glucose levels, α‐amylase activity, and endogenous antioxidants were estimated and found to be significant (P<0.05) in the rats treated with the extract of S. dulcamara at a dose of 200 mg/kg. The extract showed dose‐dependent inhibition of α‐amylase suggesting the potential benefits in glycemic control. Moreover, the study demonstrated a modulation in the activity of endogenous antioxidant enzymes (SOD, GPx, CAT). Importantly, the fruit extract showed no significant hemolysis or acute toxicity at varying concentrations (12.5 and 25 mg/mL) indicating the safe and biocompatible nature, as confirmed by normal biochemical parameters and histopathological examination. In conclusion, the methanolic fruit extract of S. dulcamara shows significant anti‐diabetic activity by alleviating oxidative stress associated with type II diabetes and its complications.
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