Abstract
To assess the suitability of concanavalin-A-induced hepatitis as a model for investigating the relationships between hepatic disease and alterations in somnolence. We characterized the sleep patterns of various strains of inbred mice undergoing ConA-induced inflammation. Southern Illinois University School of Medicine, Springfield, IL. Intravenous or intraperitoneal administration of concanavalin-A. Inbred mice. Intravenous and intraperitoneal administration of concanavalin-A both elicited strain-dependent changes in slow-wave sleep. ConA treatment also reduced spontaneous locomotor activity. ConA-induced changes in slow-wave sleep varied with dose, route of administration, and circadian period of administration. As compared with the other strains, C57BL/6J mice had lower serum concentrations of interferon-gamma at 8 hours after ConA administration. These data provide the first demonstration that sleep enhancement and reduced locomotor activity accompany hepatic inflammation in mice.
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