Abstract
BackgroundWe have developed magnetic cationic liposomes (MCLs) that contained magnetic nanoparticles as heating mediator for applying them to local hyperthermia. The heating performance of the MCLs is significantly affected by the property of the incorporated magnetite nanoparticles. We estimated heating capacity of magnetite nanoparticles by measuring its specific absorption rate (SAR) against irradiation of the alternating magnetic field (AMF).MethodMagnetite nanoparticles which have various specific-surface-area (SSA) are dispersed in the sample tubes, subjected to various AMF and studied SAR.ResultHeat generation of magnetite particles under variable AMF conditions was summarized by the SSA. There were two maximum SAR values locally between 12 m2/g to 190 m2/g of the SSA in all ranges of applied AMF frequency and those values increased followed by the intensity of AMF power. One of the maximum values was observed at approximately 90 m2/g of the SSA particles and the other was observed at approximately 120 m2/g of the SSA particles. A boundary value of the SAR for heat generation was observed around 110 m2/g of SSA particles and the effects of the AMF power were different on both hand. Smaller SSA particles showed strong correlation of the SAR value to the intensity of the AMF power though larger SSA particles showed weaker correlation.ConclusionThose results suggest that two maximum SAR value stand for the heating mechanism of magnetite nanoparticles represented by hysteresis loss and relaxation loss.
Highlights
We have developed magnetic cationic liposomes (MCLs) that contained magnetic nanoparticles as heating mediator for applying them to local hyperthermia
Those results suggest that two maximum specific absorption rate (SAR) value stand for the heating mechanism of magnetite nanoparticles represented by hysteresis loss and relaxation loss
We have demonstrated the efficacy of hyperthermia induce using MCLs in several types of tumor model; for instance, B16 melanoma in mice [7,8], T9 glioma in rats [6,9], osteosarcoma in hamsters [10], prostate cancer in mice [11] and MM46 mouse mammary carcinoma [12]. magnetite cationic liposomes (MCLs) Introduced magnetite particles transform the energy of the AC magnetic field into heat by several physical mechanisms, and its efficacy strongly depends on the frequency of the outer field as well as the particle's magnetic properties correlated to its diameter [3,13]
Summary
We have developed magnetic cationic liposomes (MCLs) that contained magnetic nanoparticles as heating mediator for applying them to local hyperthermia. MFH can raise the temperature in the tumor locally up to 41–46°C if magnetic fluid was selectively introduced and kill tumor cells directory without damages of ambient healthy cells. In this technique, magnetite particles that have ferromagnetic or superparamagnetic property are dispersed into the aqueous phase and introduced into tumor cells. Magnetite cationic liposomes (MCLs) Introduced magnetite particles transform the energy of the AC magnetic field into heat by several physical mechanisms, and its efficacy strongly depends on the frequency of the outer field as well as the particle's magnetic properties correlated to its diameter [3,13] We have demonstrated the efficacy of hyperthermia induce using MCLs in several types of tumor model; for instance, B16 melanoma in mice [7,8], T9 glioma in rats [6,9], osteosarcoma in hamsters [10], prostate cancer in mice [11] and MM46 mouse mammary carcinoma [12]. magnetite cationic liposomes (MCLs) Introduced magnetite particles transform the energy of the AC magnetic field into heat by several physical mechanisms, and its efficacy strongly depends on the frequency of the outer field as well as the particle's magnetic properties correlated to its diameter [3,13]
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