Abstract
BackgroundWe have developed magnetite cationic liposomes (MCLs) and applied them as a mediator of local hyperthermia. MCLs can generate heat under an alternating magnetic field (AMF). In this study, the in vivo effect of hyperthermia mediated by MCLs was examined using 7,12-dimethylbenz(a)anthracene (DMBA)-induced rat mammary cancer as a spontaneous cancer model.MethodMCLs were injected into the mammary cancer and then subjected to an AMF.ResultsFour rats in 20 developed mammary tumors at more than 1 site in the body. The first-developed tumor in each of these 4 rats was selected and heated to over 43°C following administration of MCLs by an infusion pump. After a series of 3 hyperthermia treatments, treated tumors in 3 of the 4 rats were well controlled over a 30-day observation period. One of the 4 rats exhibited regrowth after 2 weeks. In this rat, there were 3 sites of tumor regrowth. Two of these regrowths were reduced in volume and regressed completely after 31 days, although the remaining one grew rapidly. These results indicated hyperthermia-induced immunological antitumor activity mediated by the MCLs.ConclusionOur results suggest that hyperthermic treatment using MCLs is effective in a spontaneous cancer model.
Highlights
We have developed magnetite cationic liposomes (MCLs) and applied them as a mediator of local hyperthermia
There were 3 sites of tumor regrowth. Two of these regrowths were reduced in volume and regressed completely after 31 days, the remaining one grew rapidly. These results indicated hyperthermia-induced immunological antitumor activity mediated by the MCLs
Our results suggest that hyperthermic treatment using MCLs is effective in a spontaneous cancer model
Summary
We have developed magnetite cationic liposomes (MCLs) and applied them as a mediator of local hyperthermia. MCLs can generate heat under an alternating magnetic field (AMF). The in vivo effect of hyperthermia mediated by MCLs was examined using 7,12dimethylbenz(a)anthracene (DMBA)-induced rat mammary cancer as a spontaneous cancer model. Magnetic nanoparticles have been widely used in biological and medical fields. Magnetic separation is used to separate certain biomaterials [1] and/or cells [2,3] by using biologically labeled magnetic beads. Certain types of magnetic dispersion are used as a contrast agent in magnetic resonance imaging (MRI) diagnosis [4]. Magnetic nanoparticles have been investigated for therapeutic purposes such as hyperthermic treatment [5]. There are 2 ranges of targeting temperature used in such treatment
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