Abstract
Single oral antibiotic treatments of gonorrhea have not been universally successful. However, in this study of men who acquired gonococcal urethritis in the Philippines, a single oral dose of 3.5 gm of ampicillin with probenecid resulted in only eight failures of 202 patients (4.0%). The same dose of ampicillin without probenecid resulted in 12 failures of 41 patients (29.3%). Furthermore, single oral doses as high as 7.5 gm of phenoxymethyl penicillin were associated with higher failure rates, even with probenecid. In addition, the incidence of post gonococcal urethritis remained high regardless of the dose and duration of treatment. Therefore, a single oral dose of ampicillin with probenecid appears as a reasonable alternative to the standard treatment of acute gonococcal urethritis in men. Phenoxymethyl penicillin, on the other hand, should not be used in the treatment of gonorrhea.
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