Abstract
In a study conducted at the Alameda County Health Care Services Agency, Central Health District Venereal Disease Clinic in Oakland, California, 2.0-g and 3.0-g doses of cefazolin administered im were compared in the treatment of 149 men with acute gonococcal urethritis. The cure rates, as determined by culture, were 75% for the patients who received the 2.0-g dose and 89% for those treated with the 3.0-g dose. However, the difference in the rates of cure was not statistically significant (P > 0.12). As expected, when isolates of Neisseria gonorrhoeae obtained both before and after treatment were tested in vitro against both cefazolin and penicillin G, the organisms were shown to be more susceptible to penicillin G than to cefazolin. Adverse reactions were noted among recipients of both doses of cefazolin; discomfort at the injection site was the most common complaint. The results indicate that 2 g or 3 g of cefazolin administered im has only limited usefulness in the treatment of gonococcal urethritis in men. Further studies are needed before definitive conclusions can be made as to the efficacy of cefazolin in the treatment of gonorrhea.
Published Version
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