Single nucleotide polymorphism rs3124599 in Notch1 is associated with the risk of lung cancer in northeast Chinese non-smoking females.

Zhihua Yin,Baosen Zhou,Xue Fang,Xiaowei Quan

doi:10.18632/oncotarget.16101

Abstract

Lung cancer is one of the most common cancers and the main cause of cancer-related deaths. Notch1 might play a part in tumorigenesis of lung cancer. Here we explored the relationship of three SNPs (rs3124599, rs3124607 and rs3124594) in Notch1 with the risk and the survival of lung cancer in non-smoking females, including 556 cases and 395 controls. Chi-square tests, logistic regression analysis and crossover analysis were conducted to estimate the association between SNPs and the risk of lung cancer and the interaction between SNPs and environmental exposure. Survival analysis was conducted to explore the association between SNPs and survival of lung cancer. The results demonstrated that the polymorphism of rs3124599 was associated with the susceptibility of lung cancer in recessive model (AA+AG vs. GG). Compared to the those with AA or AG genotype, individuals with GG genotype had a 1.562-fold increased risk of lung cancer (P = 0.023, OR = 1.562, 95% CI = 1.062-2.297). In stratified analysis, the GG genotype of rs3124599 would increase the risk of small cell lung cancer (SCLC) (P = 0.011, OR = 2.167, 95% CI = 1.193-3.396). However, no significant interaction between rs3124599 and cooking oil fume exposure was observed either in addictive model or multiplicative model. The results of survival analysis showed there was no significant association between SNPs and prognosis of lung cancer (P = 0.949 for rs3124599, P = 0.508 for rs3124607, P = 0.884 for rs3124594). Our study might indicate that rs312599 in Notch1 may be a novel biomarker for SCLC risk in Chinese non-smoking females

Highlights

Lung cancer is the most frequently diagnosed cancer and the most common cause of cancer-related deaths in the worldwide
This paper studied the association between single nucleotide polymorphisms (SNPs), environmental exposure and non-smoking female lung cancer risk and survival
Genetic mutations and SNPs play a crucial role in tumorigenesis, cancer development, and prognosis of tumor

Summary

Introduction

Lung cancer is the most frequently diagnosed cancer and the most common cause of cancer-related deaths in the worldwide. 1.8 million new lung cancer cases occurred in 2012, which made up about 13% of total cancer diagnoses [1]. Smoking is the major risk of lung cancer [2]. In spite of a lower prevalence of using tobacco in China, the rate of lung cancer in Chinese females is higher than in females in some European countries[1], which means other factors, such as genetic risk factors, may play a role in the development of female lung cancer. Since women cook more than men in most Chinese families, exposure of cooking oil fume may increase the risk of non-smoking female lung cancer. This paper studied the association between single nucleotide polymorphisms (SNPs), environmental exposure and non-smoking female lung cancer risk and survival

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Results

Conclusion