Association of PPP1R13L and CD3EAP polymorphisms with risk and survival of non-small cell lung cancer in Chinese non-smoking females

Xu Feng,Lingzi Xia,Yangwu Ren,Xuelian Li,Xue Fang,Xiaowei Quan,Baosen Zhou

doi:10.18632/oncotarget.20224

Abstract

PPP1R13L and CD3EAP were confirmed to play important roles in transcription and apoptosis. SNPs in PPP1R13L and CD3EAP may be associated with lung cancer risk and survival. This study investigated the association of PPP1R13L rs1005165 and CD3EAP rs967591 with non-small cell lung cancer (NSCLC) risk and survival in Chinese non-smoking females. 442 NSCLC cases and 480 cancer-free controls were conducted in the case-control study, and 283 cases were in cohort study. Genotype was determined by Taqman real-time PCR. The statistical analyses were performed by SPSS 22.0 software. We found that rs1005165 and rs967591 were significantly associated with NSCLC risk in Chinese non-smoking females. For rs1005165, compared with homozygous wild CC genotype, carriers of CT or TT genotype had lower risk of NSCLC (adjusted ORs were 0.675 and 0.713, 95% CI were 0.461-0.988 and 0.525-0.968, respectively), adjusted OR for dominant model was 0.702, 95% CI was 0.526-0.937. For rs967591, AA genotype (adjusted OR = 0.721, 95% CI = 0.532-0.978) and at least one A allele (GA+AA) (adjusted OR = 0.716, 95% CI = 0.536-0.956) were significantly correlated with lower risk of NSCLC, compared with GG genotype. But we didn’t find correlation between the two SNPs and survival time in Chinese non-smoking NSCLC females. In general, we found PPP1R13L rs1005165 and CD3EAP rs967591 might be associated with lower NSCLC risk in Chinese non-smoking females, but no significant relationship was found with NSCLC survival.

Highlights

Lung cancer is the leading cause of cancer-related risk and mortality worldwide
This study investigated the association of PPP1R13L rs1005165 and CD3EAP rs967591 with non-small cell lung cancer (NSCLC) risk and survival in Chinese nonsmoking females
We found PPP1R13L rs1005165 and CD3EAP rs967591 might be associated with lower NSCLC risk in Chinese non-smoking females, but no significant relationship was found with NSCLC survival

Summary

Introduction

Lung cancer is the leading cause of cancer-related risk and mortality worldwide. There were 1.8 million new diagnosed lung cancer patients in 2012 and 1.59 million patients were dead because of lung cancer [1]. Epidemiological studies have confirmed that smoking was one of the risk factors for lung cancer, but only 20% of smokers will develop lung cancer [2]. About 53% female lung cancer patients are non-smokers [3], which suggest that genetic and environmental factors may have effect on lung cancer risk and development. About 80% of lung cancers are non-small cell lung carcinomas (NSCLC), and the 5-year survival rate of NSCLC is less than 20% [4]. It is meaningful to explore the factors that may be associated with NSCLC risk or survival in non-smoking females

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Results

Conclusion