Abstract
Simple, precise and economical UV Spectrophotometric methods have been developed for the simultaneous estimation of Linagliptin and Metformin in bulk and pharmaceutical dosage forms. The simultaneous equation (Vierodt's Method), which is based on measurement of absorption at 227nm and 232nm i.e. λmax of Linagliptin and Metformin respectively. Linearity was observed in the concentration range of 1–11μg/ml for Linagliptin and 3–13 μg/ml. The accuracy of methods was assessed by recovery studies and was found to be withinrange of 9899% for both Linagliptin and Metformin. The developed methods were validated with respect tolinearity, accuracy (recovery), and precision. The method can be employed for estimation of pharmaceuticalformulations with no interference from any other excipients and diluents. The results were validated statistically as per ICH Q2 R1 guidelines and were found to be satisfactory.
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