Simultaneous Presence of Acetylcholine Receptor and Muscle Specific Tyrosine Kinase Antibodies in Myasthenia Gravis

Maryam Poursadeghfard,Sara Azhdari

doi:10.34172/ijbsm.2019.01

Abstract

Myasthenia gravis (MG) is known as an autoimmune disorder which affects transmission in neuromuscular junction. The serologic tests used for diagnosis include acetylcholine receptor and muscle specific receptor tyrosine kinase antibodies. Studies often have reported that patients with formal antibody are negative for the latter one. However, very limited studies have reported positive anti-muscle specific receptor tyrosine kinase antibody in a small percentage of patients with acetylcholine receptor antibody. Here, we reported a young woman who was diagnosed with MG and had a rapid and progressive course of the disease. She was seropositive for both acetylcholine receptor and muscle-specific receptor tyrosine kinase antibodies simultaneously. However, she discharged from the hospital with good condition after treatment.

Highlights

The serologic tests used for diagnosis include acetylcholine receptor and muscle specific receptor tyrosine kinase antibodies
Myasthenia gravis (MG) is known as an autoimmune disorder which affects the transmission in neuromuscular junction
We report a young woman who was diagnosed with MG and was seropositive for both AChR and MuSK antibodies simultaneously which is a very unusual condition in MG

Summary

Introduction

Myasthenia gravis (MG) is known as an autoimmune disorder which affects the transmission in neuromuscular junction. The serologic tests used for diagnosis include acetylcholine receptor and muscle specific receptor tyrosine kinase antibodies. Very limited studies have reported positive anti-muscle specific receptor tyrosine kinase antibody in a small percentage of patients with acetylcholine receptor antibody.

Results

Conclusion