Abstract
Objectives: In this work, a new, rapid, simple, precise and specific method has been developed for the simultaneous determination of amlodipine (AML) and rosuvastatin (ROS) in pharmaceutical preparations by square wave voltammetry (SWV). Methods: Electrochemical behavior and simultaneous voltammetric determination of AML and ROS were investigated using platinum disk electrode. Validation parameters such as specificity, linearity, accuracy, precision, ruggedness, stability, limit of quantification and limit of detection were studied according to the ICH Guidelines. Results: The linearity of this developed method was established in the concentration range of 5-40 μg/mL for AML and ROS, respectively. The precision was less than 1.88 and 1.93%, determined from quality control samples for AML and ROS, and accuracy was within 1.69 and 1.97% in terms of relative error, respectively. The percentage recovery obtained for AML and ROS in pharmaceutical preparations were 99.5 and 100.2%, respectively. Limit of detection and quantification for AML were 0.70 and 2.10 µg/mL, for ROS 0.80 and 2.40 µg/mL, respectively. Conclusion: The developed SWV method can be used for routine analysis of AML and ROS in pharmaceutical preparations.
Highlights
Hyperlipidemia and hypertension are major risk factors for the development of atherosclerosis and its associated conditions such as ischemic cerebrovascular disease, coronary heart disease and peripheral vascular disease[1,2,3].Amlodipine (AML) (Figure 1a), a calcium antagonist, is prescribed for the treatment of hypertension and angina pectoris
Electrochemical behavior of AML and ROS The electrochemical behaviors of AML and ROS were investigated at the platinum working disk (Pt) disc electrode in
The Limits of detection (LOD) and LOQ values were calculated as 3.3 σ/S and 10 σ/S, respectively, where S is the slope of the calibration curve and σ is the standard deviation of y-intercept of regression equation (n=6)[20]
Summary
Hyperlipidemia and hypertension are major risk factors for the development of atherosclerosis and its associated conditions such as ischemic cerebrovascular disease, coronary heart disease and peripheral vascular disease[1,2,3]. Amlodipine (AML) (Figure 1a), a calcium antagonist, is prescribed for the treatment of hypertension and angina pectoris. It has a long elimination half-life and large volume of distribution. A few methods using HPLC were reported for the simultaneous determination of AML and ROS in pharmaceutical preparations respectively[11,12,13]. Despite the analytical importance no report has been published till today on the voltammetric study of the electrochemical oxidation of AML and ROS in non-aqueous media. This paper describes a new SWV method for the simultaneous determination of AML and ROS.
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
