Abstract
The SnO2–Zn2SnO4 nanocomposite was successfully prepared via a simple solid state method. Then, a chemically modified electrode based on incorporating SnO2–Zn2SnO4 into multi-walled carbon nanotube paste matrix (MWCNTs/SnO2–Zn2SnO4/CPE) was prepared for the simultaneous determination of morphine(MO) and codeine (CO). The measurements were carried out by application of differential pulse voltammetry (DPV), cyclic voltammetry, and chronoamperometry. The MWCNTs/SnO2–Zn2SnO4/CPE showed an efficient electrocatalytic activity for the oxidation of MO and CO. The separation of the oxidation peak potential for MO–CO was about 550mV. The calibration curves obtained for MO and CO were in the ranges of 0.1–310μmolL−1 and 0.1–600.0μmolL−1, respectively. The detection limits (S/N =3) were 0.009μmolL−1 for both drugs. The method also successfully employed as a selective, simple, and precise method for the determination of MO and CO in pharmaceutical and biological samples.
Published Version
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