Abstract
A simple biological model for the distribution of cyproterone acetate was conceived, and its pharmacokinetic was simulated by an analog computer. It could be shown that all simulated curves of drug distribution in the particular compartments agree with the experimental results of Dr. Kolb, and with pharmacokinetical reasoning. The biological model is valid for a wide range of dosage (10 - 1000 mg.) and for several routes of administration (i.v.; i.m.; i.d.; oral) in experiments with monkeys and human patients. The advantages of this analog computer method are:1Standardization of pharmacokinetic results.2Checking of biological models currently under consideration.3Coordination of the particular rate constants with the biological functions.4Determination of the optimal dosages and the best route of administration of a given drug.5Optimal efficacy of biological experiments.6Prediction of the results of biological experiments under varying conditions.
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