Abstract
Microfluidic magnetic particle trapping system was modelled, designed and manufactured to characterise and enhance the separation efficiency during sample preparation and analysis. Coupled multiphysics model of the evolving magnetic field, fluid dynamics and particle trajectories was implemented in COMSOL Multiphysics. The movement and entrapment of magnetic beads in the microfluidic magnetic separation (MMS) system were analysed and the spatial distribution of the trapped magnetic particles were compared to experimental results. For functional validation the microfluidic system was manufactured in polydimethylsiloxane (PDMS) by soft lithography technique, and special Fe-Ni patterns were deposited to locally amplify the magnetic field. The measured flow and particle motion characteristics were in good correlation with the simulations.
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