Abstract
Phospholipase D1 (PLD1) plays crucial roles in regulating multiple cell functions, including cell growth, survival, differentiation, membrane trafficking and cytoskeletal organization. Recent studies suggest that PLD1 also plays key roles in the regulation of neuronal differentiation of neural stem cells (NSCs). PLD1 is involved in the regulation of Rho family GTPases and Ca2+ dependent signaling pathways, which affect axon growth, synaptic development and plasticity. Thus, PLD1 has now attracted much attention as an essential neuronal signaling molecule in nervous system. In this review, we summarize the structure and function of PLD1 as well as its control in neuronal differentiation of NSCs and mechanisms. It is of great significance to shed light on the further study the differentiation of NSCs and neural regeneration Key words: Phospholipase; Neural stem cells; Neuronal differentiation; Signaling pathway
Published Version
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