Significance of changes of serum Clara cell secretory protein 16, pulmonary surfactant protein A in newborn infants with acute lung injury/acute respiratory distress syndrome

Abstract

Objective To investigate the effect of serum Clara cell secretory protein 16 (CC16), pulmonary surfactant protein A(SP-A) in diagnosis of acute lung injury (ALI)/acute respiratory distress syndrome(ARDS) in newborn infants. Methods Fifty ALI/ARDS newborn infants in Zhuhai People's Hospital between 2011 Sep.and Dec.2012 were selected as treatment group(ALI group including 35 cases, ARDS group including 15 cases), 50 healthy newborns were selected as healthy control group.The changes of serum CC16, SP-A were detected by enzyme-linked immuno sorbent assay and were compared in the 3 groups. Results 1.Serum CC16 in ALI group and ARDS group were (34.19±1.09) mg/L, (55.28±0.82) mg/L, respectively, which were significantly higher than that in healthy control group [(12.67±1.10) mg/L](all P<0.05), and there was significant difference between ALI group and ARDS group(P<0.05).2.Serum SP-A in ALI group and ARDS group were(56.78±3.48) mg/L, (70.23±5.14) mg/L respectively, which were significantly higher than that in healthy control group [(22.10±3.32) mg/L](all P<0.05), and there was significant difference between ALI group and ARDS group(P<0.05). Conclusion Serum CC16, SP-A can be effective parameter for early monitoring ALI/ARDS in newborn infants. Key words: Acute lung injury; Acute respiratory distress syndrome; Newborn infant