Abstract
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Highlights
Nikolenko et al, following in the footsteps of holography pioneer Gabor (1948), deliberately perturb the phase of the input light to the objective
The high power needed for two-photon uncaging currently acts as a barrier to selecting more than a modest number of spots
The second application was to image activity, via a calcium indicator, simultaneously in multiple neurons at speeds ranging from 15-60 Hz
Summary
Nikolenko et al (and related work Lutz et al, 2008; Papagiakoumou et al, 2008), following in the footsteps of holography pioneer Gabor (1948), deliberately perturb the phase of the input light to the objective. The ability to stimulate multiple spots seems likely to yield advances in our understanding of both single-cell membrane properties and neuronal circuits. SLM microscopy exploits our burgeoning ability to shape light to our needs, and is a welcome addition to the overall progress in optics and neuroscience.
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