Shared versus non-shared prepulse perfusion MR sequence in absolute myocardial perfusion quantification

Abstract

Methods In this substudy of the NOMI-trial (ClinicalTrials.gov identifier: NCT01398384), quantitative perfusion analysis was compared between patients that underwent an MR first pass perfusion sequence with a shared (n=25) and a non-shared prepulse (n=25), at 4 months after revascularized myocardial infarction. Perfusion imaging consisted of 3 short-axis slices acquired every heartbeat, with a balanced turbo gradient echo sequence in a 1.5 tesla MR unit (Achieva, Philips Medical Systems, The Netherlands) and was performed at rest and during adenosine (140 μg/kg/min) stress. MBF was quantified using Fermi deconvolution with a single bolus (SB, 0.05 mmol/kg) and dual bolus (DB, equal volumes of 0.0027 mmol/kg followed by 0.05 mmol/kg of contrast agent) analysis technique, in 6 segments of basal and midventricular short axis slices. Apical segments and segments with infarct scar on the corresponding late gadolinium enhancement-images were excluded. Results Baseline characteristics of both patient groups were comparable. MBF values were significantly higher with SP than with NSP sequence for the SB analysis technique. For DB, MBF was not different for rest perfusion,