Abstract
Some health technology assessment (HTA) agencies incorporate severity weighting in health economic evaluations to prioritize interventions for severe diseases. Measures like absolute and proportional shortfall are used to quantify disease severity; decision modifiers are then applied to increase the value of quality-adjusted life-year gains for severe conditions. This paper reviews studies that measure societal preferences for prioritizing severity, as well as current methods used by HTA agencies to incorporate severity weighting into economic evaluations. The review of the literature highlights preferences to reduce unfair health variations, with most studies indicating a willingness to prioritize the severely ill. A review of approaches conducted by HTA agencies found variation in how severity weighting was incorporated and valued. Further research is needed to better understand societal values regarding severity and the appropriate weighting of disease severity for economic evaluations within Canada.
Published Version
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