Serum values of cytokines in patients with ischemic heart disease and arterial hypertension.

Abstract

The studied levels of cytokines (levels of Pro-inflammatory cytokine - interleukin-1β, anti-inflammatory cytokine - interleukin-10, CD40 ligand (CD40L)) in patients with arterial hypertension and ischemic heart disease. Indicators of Pro-inflammatory cytokine - interleukin-1β and anti-inflammatory cytokine - interleukin-10 were significantly increased in patients with arterial hypertension and ischemic heart disease compared with values in healthy individuals. Elevated interleukin-1β and CD40L in patients with arterial hypertension and ischemic heart disease compared with values in healthy individuals indicate inflammatory process in the endothelium. An increase in the IL-10 may indicate the presence of chronic systemic inflammation, in which vascular endothelium is likely to take an active part. Long-term high IL-1β rates lead to increased activity of cells of species immunity, whose metabolic products are involved in the activation of the adrenal glands. Thus, the cytokine profile disorder can be considered as an additional laboratory indicator of atherosclerotic vascular damage.