Abstract
INTRODUCTION: Acute ischemic stroke (AIS) is a significant disease burden globally. However, its association with raised serum uric acid (SUA) levels remains controversial. Thus, we evaluated the uric acid level in the first episode of AIS and assessed the association of SUA levels with the severity of AIS and functional disability produced. MATERIALS AND METHODS: This single-center, case–control study was performed in the Department of Medicine of a tertiary care institute, over a period of 24 months. Cases included patients with the first episode of AIS proven on computed tomography or magnetic resonance imaging. SUA levels were estimated in cases (n = 50) and matched controls (n = 50) within 24-h of admission. Among cases, the severity of stroke was assessed by the National Institutes of Health Stroke Scale (NIHSS) score, and a modified Ranking Score (mRS) was used for evaluating the disability. RESULTS: Hyperuricemia was present in 88% of cases. The mean SUA levels were significantly higher among cases relative to controls (7.78 ± 1.26 mg/dl vs. 5.24 ± 1.18; P < 0.0001). Based on the NIHSS score and mRS, most of the patients had a severe stroke (56%) and moderate functional disability (40%), respectively. Among cases, SUA levels had a moderate and significantly positive correlation with NIHSS score (r = 0.527, P < 0.0001), and mRS (r = 0.533, P < 0.0001). However, SUA levels were not significantly associated with comorbidities, including diabetes mellitus, hypertension, obesity, and ischemic heart disease (all P > 0.05). CONCLUSION: Hyperuricemia is highly prevalent among patients with AIS, and it is positively and significantly correlated with NIHSS score and mRS.
Published Version
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