Abstract
Introduction: Uric acid has been proven to be a negative prognostic indicator in patients with acute myocardial infarction and heart failure. There is a need to find a simple, less expensive but accurate marker that could be use in rural areas where fibrinolytic treatment is the first choice of acute reperfusion therapy. Materials and Methods: 80 patients presenting with acute myocardial infarction were included in the study and serum uric acid levels and Killip Class was assessed on Day 0,3 and 7. Results: Serum uric acid levels were raised in patients who presented with higher Killip Class on admission and all the 6 patients who succumbed belonged to either Killip Class 3 or 4 at presentation with a serum uric acid level of more than or equal to 7mg/dL. Conclusion: Serum uric levels are raised during an episode of myocardial infarction and more so when the patient is in heart failure. There is a positive correlation between rising serum uric acid levels with higher Killip Class at the time of admission. Thus uric acid can be used as a prognostic indicator in patients presenting with myocardial infarction more so if they are in heart failure.
Highlights
Uric acid has been proven to be a negative prognostic indicator in patients with acute myocardial infarction and heart failure
Increased serum uric acid (SUA) levels is linked to various cardiovascular diseases (CVD) risk factors like hypertension, dyslipidemia, diabetes, metabolic syndrome making it difficult to assess if it was the cause or effect of such conditions.[1,2]
Our study included 80 patients who presented with Acute myocardial infarction (AMI) (STEMI and NSTEMI) out of which 55 were males & 25 were females
Summary
Uric acid has been proven to be a negative prognostic indicator in patients with acute myocardial infarction and heart failure. Increased serum uric acid (SUA) levels is linked to various CVD risk factors like hypertension, dyslipidemia, diabetes, metabolic syndrome making it difficult to assess if it was the cause or effect of such conditions.[1,2] Acute myocardial infarction (AMI) is the most dramatic manifestation of coronary artery disease (CAD). A recent retrospective analysis from Japan showed a univariate associate between higher SUA on admission & higher 30 day mortality in AMI patients.[3] Killip Classification is a simple clinical tool constructed by Killip & Kimbal, to clinically stratify patients in heart failure They were classified into four classes based on clinical examination. Patients with higher Killip Class on admission for AMI showed more severe angiographic CAD. 4 Though many cardiac biomarkers are being assayed, occasionally there is a need to find a simple & accurate prognostic marker in developing countries where fibrinolytic therapy is still the first choice of reperfusion therapy either due to nonavailability of percutaneous coronary intervention or due to financial constraints
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
