Abstract
Background: Male and female brain develops differently. Gender is one of biological variables that influence visual evoked potentials (VEP). Some previous studies support the existence of sex related VEP difference while others not. This study is an attempt to explore if any difference exists in VEP responses between genders of children age seven to 10 years with an additional aim of documenting preliminary normative VEP data.Methods: This cross-sectional study was done on consenting children taken from parents (n=76; girls, n=41, age = 8.39±1.11years; boys, n=35, age =8.40±1.09 years). Pattern reversal VEP of these children was recorded as per standard method. Latencies of N75, P100, and N145 (ms); amplitude of P100 (μV) and ratio; interocular asymmetry (ms) of both eyes were calculated. Unpaired t-test was applied for statistical analysis. Ethical clearance was obtained prior to the study. Result: Girls had decreased VEP latency of P100 than boys in left eye (108.15±8.42 vs. 112.71±11.17ms, p = 0.046), in right eye (107.71±8.52 vs. 114.46±10.98 ms, p = 0.004), and in combination of both eyes (107.92±8.07 vs. 113.58±10.36 ms, p = 0.009). Likewise, girls had decreased VEP latency of N75 than boys in right eye (67.44±6.77 vs. 71.29±8.07 ms, p = 0.027) and in combined eyes (67.23±5.19 vs. 70.14±7.31 ms, p = 0.047). A gender difference in P100 amplitude was not detected.Conclusion: Visual evoked potential differs with gender in prepubertal children aged seven to 10 years.
Highlights
Visual evoked potentials (VEP) are visually evoked electrophysiological signals extracted from the electroencephalographic activity in the visual cortical areas 17, 18 and 19 recorded from the overlying scalp to visual stimulation[1, 2]
The effect of sex on VEPs in the literature was often assessed by the authors as secondary objectives with sample including from children to elderly[9, 10]
This study is an attempt to explore if any difference exists in VEP responses between genders of children age seven to 10
Summary
Visual evoked potentials (VEP) are visually evoked electrophysiological signals extracted from the electroencephalographic activity in the visual cortical areas 17, 18 and 19 recorded from the overlying scalp to visual stimulation[1, 2]. Visual evoked potentials (VEP) are known to be influenced by several biological variables, including sex. Some previous studies support the existence of sex-related VEPs differences in children while others do not [3,4,5,6,7,8]. This study is an attempt to explore if any difference exists in VEP responses between genders of children age seven to 10. Some previous studies support the existence of sex related VEP difference while others not. This study is an attempt to explore if any difference exists in VEP responses between genders of children age seven to 10 years with an additional aim of documenting preliminary normative VEP data. Conclusion: Visual evoked potential differs with gender in prepubertal children aged seven to 10 years
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