Abstract
Background: Metabolic diseases are affecting human health all over the world. These chronic disease states are associated with high sensitive CRP. The present study aims to measure hsCRP and lipid levels in a group of healthy adults to work out the normal hsCRP levels and explore its relationship to lipidemic and anthropometric variables.Materials and Methods: A total of 149 adults, age 30-60 yrs, healthy subjects were recruited in this study. Vital statistics were taken along with measurement of blood glucose, triglyceride, total cholesterol, high density lipoprotein, low density lipoprotein and hsCRP levels. Data were analyzed using statistical Package for Social Program (SPSS) for Windows version 10.Results: Mean (±SD) hsCRP was 2.46±1.89 (mg/l) with a cut off value of 3mg/l. Of the total 149 subjects 102 (66.4%) and 47 (31.5%) subjects had hsCRP level below and above the cutoff respectively. Triglyceride was significantly higher (p=0.033) and HDL was lower in subjects with high hsCRP. Total cholesterol and LDL was almost similar in both groups. Binary logistic regression showed significant negative association between hsCRP and HDLc (p=0.029) and but the model excluding HDL-c showed significant positive association (p=0.03) with triglyceride.Conclusion: About one-third of healthy Bangladeshi adults may have chronic subclinical inflammation and thus may have a risk of cardiovascular disorders. More than one-third healthy Bangladeshi adults have one or more type of dyslipidemia and the subclinical chronic inflammation in healthy Bangladeshi adults has a positive association with their serum triglyceride and negative association with their HDL-cholesterol levels.DOI: http://dx.doi.org/10.3126/jpn.v4i8.11591 Journal of Pathology of Nepal; Vol.4,No. 8 (2014) 644-648
Highlights
C-reactive protein (CRP) is an inflammatory marker whose expression is markedly up regulated during inflammation.[1]Correspondence: It is the acute phase protein synthesized in the liver and regulated to a large extend by pro-inflammatory cytokine interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-α).[2]
High sensitivity CRP and lipidemic status abnormalities related to insulin resistance, such as increase in fasting insulin, body mass index (BMI), systolic blood pressure and triglyceride (Tg) as well as decrease in high density lipoprotein cholesterol (HDL-C).[6,7,8]
An invitation was made to the volunteer of the study through personal contact to report in the department of Biochemistry and Physiology, Bangladesh Institute of Research & rehabilitation for Diabetes, Endocrine and Metabolic Disorders (BIRDEM) and requested to refrain from fatty meal for 24 hrs preceding date of appointment
Summary
C-reactive protein (CRP) is an inflammatory marker whose expression is markedly up regulated during inflammation.[1]Correspondence: It is the acute phase protein synthesized in the liver and regulated to a large extend by pro-inflammatory cytokine interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-α).[2]. Studies have shown high level of high sensitive C- reactive protein (hsCRP) in subjects with type 2 diabetes mellitus and dyslipidemia. Data are lacking regarding lipidemic status and hsCRP level in a well-defined group of healthy subjects in Bangladeshi population. In this perspective current study was done to measure hsCRP in the serum of Bangladeshi healthy adults and to explore its association with their lipidemic status. Metabolic diseases are affecting human health all over the world. These chronic disease states are associated with high sensitive CRP. The present study aims to measure hsCRP and lipid levels in a group of healthy adults to work out the normal hsCRP levels and explore its relationship to lipidemic and anthropometric variables
Sign-in/Register to view highlights & summary 
Published Version (
Free)
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call