Abstract
Abstract Background: High leptin level is associated with childhood obesity-related comorbidities including metabolic syndrome (MS). Objective: We aimed to find out serum leptin level in obese adolescents with MS. Materials and Methods: This prospective study was conducted in the Department of Pediatrics, Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh, from November 1, 2022, to October 31, 2023, including 60 obese adolescents aged 10–16 years as cases and 25 nonobese adolescents as control. Serum leptin level was compared between those two groups and in adolescents with or without MS. Analysis: The data were analyzed by Statistical Package for Social Sciences computer software version 22 using unpaired Student’s t test, Chi-square test, Pearson’s correlation, and linear regression analysis. A P value of <0.05 was considered statistically significant. Results: Serum leptin level was significantly higher (P = 0.004) in obese adolescents than in the control group. MS was found in 63.3% of obese adolescents, and the leptin level was significantly higher among them (P = 0.000). It was significantly related to waist circumference (P = 0.000), both systolic blood pressure (P = 0.010) and diastolic blood pressure (P = 0.000), blood sugar level 2 h after glucose administration (P = 0.000), triglyceride (P = 0.000) and high-density lipoprotein level (P = 0.026). In the multivariate analysis, no determinant factor was found. Conclusion: Serum leptin levels are higher in obese adolescents having MS.
Published Version
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