Abstract
BackgroundThe study aims to associate serum insulin-like growth factor-1 (IGF-1) levels with cervical maturation stages (CS) 3, 4, and 5 on lateral cephalogram in male subjects and to find out peak serum IGF-1 levels among these three stages.MethodsThe study was conducted on 45 male subjects who were at skeletal maturation stage CS-3, CS-4, and CS-5. Subjects were selected using simple random sampling technique. Serum IGF-1 levels were estimated from blood samples using chemiluminescence immunoassay (CLIA) method. CS was evaluated using a six-stage method of evaluating the cervical vertebrae. Mean IGF-1 levels between the stages were compared by analysis of variance (ANOVA) test.ResultsOne-way ANOVA showed highly significant differences between all cervical stages with p value <0.01, but post hoc Tukey test showed highly significant differences between CS-4 and CS-5 with p value 0.006. Serum IGF-1 levels showed good association with skeletal age in male subjects; 53.3% of subjects at CS-3, 66.7% subjects at CS-4, and 6.7% subjects at CS-5 showed IGF-1 levels in peak range.ConclusionsSerum IGF levels can be used as an additional tool to optimize orthodontic treatment timing.
Highlights
The study aims to associate serum insulin-like growth factor-1 (IGF-1) levels with cervical maturation stages (CS) 3, 4, and 5 on lateral cephalogram in male subjects and to find out peak serum IGF-1 levels among these three stages
The sample used in the study consisted of 45 male subjects, who were at CS-3, CS-4, and CS-5, selected from the patients coming to the Department of Orthodontics and Dentofacial Orthopedics and Department of Pedodontics at our institute by simple random technique
Inclusion criteria were male subjects who were at CS-3, CS-4, and CS-5 based on information about birth date and their good health status
Summary
The study aims to associate serum insulin-like growth factor-1 (IGF-1) levels with cervical maturation stages (CS) 3, 4, and 5 on lateral cephalogram in male subjects and to find out peak serum IGF-1 levels among these three stages. The classic method of assessing skeletal maturity is by the use of a hand-wrist radiograph. Assessing the degree of cervical vertebral maturation on lateral cephalometric radiograph [1,2,3,4,5,6,7,8] and recording MP3 stages [9,10] on periapical X-ray films are used to identify peak mandibular bone growth and skeletal maturity. If the shape of the cervical vertebrae does not show the exact stage, additional method can be of use to predict the maturation stage accurately
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