Serum insulin-like growth factor-1 levels in females and males in different cervical vertebral maturation stages

Shreya Gupta,Anuradha Deoskar,Sandhya Jain,Puneet Gupta

doi:10.1590/2176-9451.20.2.068-075.oar

Abstract

OBJECTIVE: The aim of this cross sectional study was to assess serum insulin-like growth factor-1 (IGF-1) levels in female and male subjects at various cervical vertebral maturation (CVM) stages. MATERIAL AND METHODS: The study sample consisted of 60 subjects, 30 females and 30 males, in the age range of 8-23 years. For all subjects, serum IGF-1 level was estimated from blood samples by means of chemiluminescence immunoassay (CLIA). CVM was assessed on lateral cephalograms using the method described by Baccetti. Serum IGF-1 level and cervical staging data of 30 female subjects were included and taken from records of a previous study. Data were analyzed by Kruska-Wallis and Mann Whitney test. Bonferroni correction was carried out and alpha value was set at 0.003. RESULTS: Peak value of serum IGF-1 was observed in cervical stages CS3 in females and CS4 in males. Differences between males and females were observed in mean values of IGF-1 at stages CS3, 4 and 5. The highest mean IGF-1 levels in males was observed in CS4 followed by CS5 and third highest in CS3; whereas in females the highest mean IGF-1 levelswas observed in CS3 followed by CS4 and third highest in CS5. Trends of IGF-1 in relation to the cervical stages also differed between males and females. The greatest mean serum IGF-1 value for both sexes was comparable, for females (397 ng/ml) values were slightly higher than in males (394.8 ng/ml). CONCLUSIONS: Males and females showed differences in IGF-1 trends and levels at different cervical stages.

Highlights

Assessment of growth status plays a vital role in orthodontic treatment planning decisions, including cases involving the use of functional appliances, rapid maxillary expansion, retention appliances, extraoral traction forces, extraction versus non-extraction treatment or orthognathic surgery.[1]Growth modification therapy carried out during the adolescent growth spurt might allow successful outcomes to be achieved within a reduced period of time.[2]
Highest mean insulin-like growth factor-1 (IGF-1) value was observed in CS4 with a mean value of 394.8 + 50.89 ng/ml at a mean age of 14.08 years
The second highest mean IGF-1 was observed at CS5 followed by CS3

Summary

Introduction

Assessment of growth status plays a vital role in orthodontic treatment planning decisions, including cases involving the use of functional appliances, rapid maxillary expansion, retention appliances, extraoral traction forces, extraction versus non-extraction treatment or orthognathic surgery.[1]Growth modification therapy carried out during the adolescent growth spurt might allow successful outcomes to be achieved within a reduced period of time.[2]. Assessment of growth status plays a vital role in orthodontic treatment planning decisions, including cases involving the use of functional appliances, rapid maxillary expansion, retention appliances, extraoral traction forces, extraction versus non-extraction treatment or orthognathic surgery.[1]. According to Hagg et al,[5] the optimal age of maxillary expansion in girls is 12 to 13 years. In boys, maxillary inter-canine dimensions increase is seen until the age of 18. The clinical implication is that, in cases of crowding, any attempt to treat by expansion may not succeed due to the inability to attain a stable increase in inter-canine width. Determining the growth trend in each patient becomes crucial for the orthodontic practitioner

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Conclusion