Abstract
The objective of this study is to incorporate serum Ferroxidase/Albumin ratio as a surrogate marker to assist in diagnosis of pulmonary tuberculosis. Forty cases of sputum for acid fast bacilli positive PTB patients compared with forty healthy controls. Serum Ferroxidase activity of Ceruloplasmin was determined by end point method using Ferrous Ammonium Sulphate Hexahydrate at 600nm. Serum Albumin was determined by Bromocresol green, dye binding method at 628nm. Mean
Highlights
Tuberculosis is a curable infectious disease causing significant morbidity and preventable deaths worldwide
One third of the global population is infected with TB, of which 95% of the incidence is in developing countries[2].According to US center for disease control and prevention, laboratory criteria for diagnosis of TB include isolation of Mycobacterium TB from a clinical specimen, demonstration of MTB from a clinical specimen by Nucleic Acid amplification Test and Demonstration of Acid Fast bacilli in a clinical specimen when a culture has not been or cannot be obtained[3]
Radiometry using BACTEC instrument is used to reduce the diagnostic time in cultured specimens
Summary
Tuberculosis is a curable infectious disease causing significant morbidity and preventable deaths worldwide. One third of the global population is infected with TB, of which 95% of the incidence is in developing countries[2].According to US center for disease control and prevention, laboratory criteria for diagnosis of TB include isolation of Mycobacterium TB from a clinical specimen, demonstration of MTB from a clinical specimen by Nucleic Acid amplification Test and Demonstration of Acid Fast bacilli in a clinical specimen when a culture has not been or cannot be obtained[3]. Studies have reported that MDR-TB is significantly higher among treatment failures This can be prevented by early referral for culture. Radiometry using BACTEC instrument is used to reduce the diagnostic time in cultured specimens. Still, using this technique, organisms can be detected only after 7 to 8 days in smear positive patients[5]
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