Serum Adiponectin and Leptin Levels and Their Relations withInflammatory Factors and Metabolic Syndrome

Abstract

Background: Metabolic syndrome, associated with adipose-derived hormones, is known as an important risk for diabetes and cardiovascular disease. We measured serum adiponectin and leptin levels of 577 health-check patients and analyzed the relations with inflammatory factors and metabolic syndrome diagnosis. The results showed that serum leptin had high tightly correlations with waist circumference, body mass index and serum E-selectin; meanwhile, serum adiponectin had highest correlation with HDL-C level. For detecting the metabolic syndrome in both males and females, adiponectin had better sensitivity and specificity than leptin. After adjusting for age, waist and body mass index, the odds ratio (95% confidence interval) for metabolic syndrome corresponding to 1 mg/L decrease in adiponectin was 1.32 (1.13-1.54) in males and 1.16 (1.04-1.3) in females. In contrast, leptin showed no significant association with metabolic syndrome. In conclusion, serum adiponectin and leptin correlated with characteristics of metabolic syndrome and chronic inflammation. However, only adiponectin was risk factor for metabolic syndrome independent of age and obesity.