Abstract

Objective To investigate the effects of serum adiponectin,leptin levels on motor functional outcome in the patients with acute cerebral infarction.Methods Forty-five patients with acute cerebral infarction and 30 healthy cases were selected as study group and control group.Motor functional outcome was evaluated by Fugl-Meyer score.Serum adiponectin and leptin levels were detected by enzyme linked immunosorbent assay.The correlation between serum adiponectin,leptin levels and motor functional outcome was assessed.Results Serum adiponectin level in control group [(13.78 ±4.25) mg/L] was higher than that in study group[(6.35 ± 3.18) mg/L],and there was significant difference between two groups (P ＜ 0.05).Serum leptin level in control group [(6.48 ± 1.26) μ g/L] was lower than that in study group [(20.35 ± 2.59) μg/L],and there was significant difference between two groups (P ＜0.05).There was significant difference in serum adiponectin and leptin levels among different Fugl-Meyer score in study group (P ＜ 0.05).Serum adiponectin level had positive correlation with Fugl-Meyer score (r =0.528,P ＜ 0.05).Serum leptin level had negative correlation with Fugl-Meyer score (r =-0.564,P＜ 0.05).There was negative correlation between serum adiponectin levels and serum leptin levels (r =-0.427,P ＜ 0.05).Conclusions Adiponectin and leptin is associated with pathogenesis of acute cerebral infarction.The correlation between serum adiponectin,leptin levels and motor functional outcome is close. Key words: Brain infarction; Adiponectin; Leptin; Fugl-Meyer score

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