Abstract

Background: Diabetes mellitus is a metabolic characterized bydeficiency of insulin and insulin resistance. Adenosine deaminase (ADA) modulates the bioactivity of insulin and Adenosine receptorsstimulate glucogenolysis and gluconeogenesis . but its role in Type 2 diabetes mellitus is not yet characterized. Aim & Objectives : The present study aimed to evaluate the serum Adenosine Deaminase level and to correlate ADA levels with Blood Glucose and Glycated hemoglobin levels in Type-2 Diabetes Mellitus patients. Material and Method: The study population of 120 patients were divided into 3 groups: Group A which consisted of 40 normal healthy individuals without any complication or history of Diabetes. Group B included 40 patients of Type 2 Diabetes Mellitus both with HbA1c 7% (n=40). Fasting blood sugar, HbA1c, ADA, and body mass Index were estimated in all the subjects under study. Results: The study showed that mean Fasting Blood Sugar, Post prandial Blood sugar and HbA1c concentration was significantly higher in Group C & Group B compared to Group A. Compared with the well-controlled Type-2 Diabetes Mellitus patients (HbA1c 7%) showed significantly increased ADA activity (49.79 18.12 U/L vs. 90.10 32.75; P <0.001). The correlation between Adenosine Deaminase and HbA1c was positive and significant in both Group B (r= 0. 389; p= 0.007) and Group C (r = 0.430; p<0.001). Conclusion: Serum ADA levels may have an important role in determining the glycemic status in Diabetics. A positive correlation between ADA level with glycemic control suggest its important role in glucose and lipid metabolic derangements seen in Type 2 Diabetes Mellitus patients.

Highlights

  • The prevalence of diabetes is rapidly rising at an alarming rate all over the world

  • Aim & Objectives: The present study aimed to evaluate the serum Adenosine Deaminase level and to correlate Adenosine deaminase (ADA) levels with Blood Glucose and Glycated hemoglobin levels in Type-2 Diabetes Mellitus patients

  • Serum ADA levels increase with increase in FBS and glycated haemoglobin levels which may have an important role in determining the glycemic status in Diabetics

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Summary

Introduction

The prevalence of diabetes is rapidly rising at an alarming rate all over the world. Over the past 30 years, the status of di abetes has changed from being mild disorder of the elderly to one of the major causes of morbidity and mortality affecting the youth and middle aged people. Aim & Objectives: The present study aimed to evaluate the serum Adenosine Deaminase level and to correlate ADA levels with Blood Glucose and Glycated hemoglobin levels in Type-2 Diabetes Mellitus patients. Group B included 40 patients of Type 2 Diabetes Mellitus both with HbA1c < 7%. Group C consisted of 40 patients of Type 2 Diabetes Mellitus with HbA1c >7% (n=40). Compared with the well-controlled Type-2 Diabetes Mellitus patients (HbA1c < 7%), the poorly controlled group (HbA1c > 7%) showed significantly increased ADA activity (49.79± 18.12 U/L vs 90.10± 32.75; P

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