Serum 1, 25-dihydroxy vitamin D- vitamin D3- among obese Egyptian women with polycystic ovary syndrome

Zakia Mahdy Ibrahim,Omima Tharwat Taha,Sara Mohamed Fahmy,Eman Ahmed Kishk

doi:10.15761/ogr.1000141

Abstract

Serum 1, 25-dihydroxy vitamin D- vitamin D3- among obese Egyptian women with polycystic ovary syndrome

Highlights

Polycystic ovary syndrome (PCOS) is the most common female endocrine disorder, affecting approximately 4%–18% women of reproductive age [1]
All patients were diagnosed as having PCOS and were allocated to either group according to their BMI
All patients fulfilled 2003 revised Rotterdam diagnostic criteria based on the association of at least two of the three following criteria: (a) Oligomenorrhea defined as cycles at intervals > 45 days or amenorrhea defined as absent cycles more than three months. (b) Clinical Hyperandrogenism (the presence of hirsutism, acne, or androgenic alopecia.) or hyperandrogenemia (total testosterone>0.7 ng/ml. (c) Ultrasound criterion of polycystic ovary syndrome, either; 1) Presence of 12 or more follicles in each ovary measuring 2-9 mm in diameter, 2) And/or increased ovarian volume (>10 mL), 3) And/or an ovarian area more than 5.5 cm2 unilaterally or bilaterally

Summary

Introduction

Polycystic ovary syndrome (PCOS) is the most common female endocrine disorder, affecting approximately 4%–18% women of reproductive age [1]. It is a heterogeneous androgen-excess disorder causing multiple reproductive and metabolic dysfunctions with variable degrees. The diagnostic criteria in adult women include chronic anovulation manifested as amenorrhea or oligomenorrhea, polycystic ovarian morphology, and hirsutism or acne as evidences of hyper-androgenism. Intrinsic abnormalities in ovarian steroidogenesis may underlie this ovarian dysfunction in some patients [4]. Additional factors, such as insulin resistance and/or hyperinsulinemia, may play a significant role. Similar to diabetes, PCOS is not one disorder/disease [5]

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Discussion

Conclusion