Abstract
Metastatic mixed gestational trophoblastic tumour of the uterus: A case report
Highlights
IntroductionA mixed gestational trophoblastic neoplasia (GTN) is a very rare, histologically heterogeneous form of tumour, generally made up by choriocarcinoma and/or placental site trophoblastic tumour (PSTT) and/or epithelioid trophoblastic tumour (ETT) [1,2,3]
Mixed gestational trophoblastic neoplasms are treated with hysterectomy and careful lymph node dissection; metastatic cases are treated with adjuvant chemotherapy [6]
The difficulty in diagnosing a mixed gestational trophoblastic neoplasia (GTN) resides in the fact that the slightly elevated β-HCG is an ambiguous lab finding, albeit not compatible with a pure choriocarcinoma and the fact that there is no fixed MRI pattern for GTNs, both pure and mixed; they tend to be infiltrative heterogeneously necrotic masses, extending to the myometrium and beyond, with some cystic colliquation and variable vascularization, which tends to be extreme in the case of choriocarcinoma, leading to hematogenous metastases
Summary
A mixed gestational trophoblastic neoplasia (GTN) is a very rare, histologically heterogeneous form of tumour, generally made up by choriocarcinoma and/or placental site trophoblastic tumour (PSTT) and/or epithelioid trophoblastic tumour (ETT) [1,2,3]. The most common combination is a choriocarcinoma mixed with an ETT and/or PSTT [4]. Considering the diagnosis of pure forms of GTNs is challenging itself - PSST, for example, has a prevalence of
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