Abstract
The kinetic pattern of molecular events in the regenerating liver of rats was studied under closely controlled conditions to minimize deviation in the degree of synchronization. The activities of DNA polymerase (EC 2.7.7.7), thymidine kinase (EC 2.7.1.75) and ribonucleoside diphosphate reductase were increased several fold by partial hepatectomy; the latter two enzymes exhibited a biphasic pattern of induction coupled to the initial two cycles of nuclear DNA replication. A biphasic 45–60% maximal change in the template activity of chromatin for Escherichia coli RNA polymerase preceded by several hours each wave of DNA synthesis and enzyme induction. The results suggest that the changes in the template activity of chromatin and the activities of enzymes necessary to support DNA biosynthesis are sequential and related events which are tightly regulated in regenerating liver.
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