Sensitivity Analysis of Genetic Algorithms for Optimization of Operating Conditions for Protein Production Plants

Abstract

This work introduces genetic algorithms, which will be investigated and used to perform sensitivity analysis. Genetic algorithms are part of a collection of stochastic optimization algorithms based on the concepts of biological evolutionary theory. This research deals with the problem of the search for optimal investment cost of multiproduct batch chemical plants found in a chemical engineering process with uncertain demand. The aim of this work is to minimize the investment cost and find out the number and size of parallel equipment units in each stage. For this purpose, it is proposed to solve the problem by using Genetics Algorithms (GAs). This GAs consider an effective mixed continuous discrete coding method with a four point crossover operator, which take into account, the uncertainty on the demand using Gaussian process modeling. Experiments indicated that relatively good results could be obtained using 4-point crossover with an applied rate of 0.7 and mutation rate ranged between 0.01 and 0.09 promised to give best performance. The results (number and size of equipment, investment cost, production time (Hi), CPU time and Idle times in plant) obtained by GAs are much more rapidly than mixed integer linear programming. This methodology can help the decision makers and constitutes a very promising framework for finding a set of “good solutions”.