Abstract
A composite material comprised of graphene nanoplatelet and silver particles (GNPs–AgPs) was used for the deposition of GNPs–AgPs’ nanofilms with cold plasma on silk. α-Cyclodextrin was used as a modifier of the active surface of the disposable sensor. The disposable stochastic sensor was used in screening tests for the assay of heregulin-α in whole blood and tissue samples. The disposable stochastic sensor showed a low limit of determination (4.10 fg mL−1) and can be used with high sensitivity on a wide concentration range (4.10 fg mL−1–0.04 µg mL−1). The screening method was validated against ELISA when good correlations (confirmed also by the t-test) were obtained.
Highlights
Heregulins (HRGs) are members of the epidermal growth factor (EGF) family of peptides
The HRG-α solutions were used for 1 month; when they were not used for measurements, the solutions were stored in a fridge (2–8 ◦ C)
Optical microscope images for the uncoated and coated silk textile surfaces are The samples were illuminated by reflected techniques and the images are directly shown
Summary
Heregulins (HRGs) are members of the epidermal growth factor (EGF) family of peptides. The HRG-α plays an important role in the development, regeneration, and tumor formation of the nervous system, including stimulation of acetylcholine receptor synthesis [2] and mitogenesis for Schwann cells, and can provide good information regarding brain tumors [3]. This has been shown to be difficult to treat due to the biological characteristics in the types of cancers, which frequently limit its evolution. Due to the importance of HRG-α in the diagnosis and follow-up of treatments for brain cancer, there is a huge need to develop fast screening methods and tools for its detection and quantification in biological samples, such as whole blood and brain tumor tissue samples
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