Abstract
Background c.12,000 people work with laboratory animals in the UK. Historical data suggests 15% develop specific IgE sensitisation to laboratory animal proteins and 10% clinical symptoms of laboratory animal allergy (LAA). Individually ventilated cages (IVC) are replacing conventional cages; lower ambient aeroallergen levels are reported but no reduction in LAA incidence is yet apparent. Aim To explore the contemporary risks of working with mice. Methods A cross-sectional survey at UK research institutions is underway. Primary outcome is comparison of prevalence of sensitisation to mouse proteins in IVC-only and mixed facilities (open cages+/- IVCs). Participants complete a questionnaire about work practices and allergic symptoms. Skin-prick tests are performed and serum analysed for specific IgE to Mus m 1 and mouse epithelium. Detailed exposure measurements are also made. Results 526 participants have been recruited to date; analyses are restricted to those with Conclusion In contemporary practice, the prevalence of sensitisation to mouse proteins is low and significantly lower in IVC facilities. Ongoing work will determine how individual practice at different institutions may influence development of sensitisation.
Published Version
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