Abstract
A single solid tumor, composed of nearly identical cells, exhibits heterogeneous dynamics. Dynamics of cells in the core is glass-like, whereas those in the periphery undergoes diffusive or super-diffusive behavior. Quantification of heterogeneity using the mean square displacement or the self-intermediate scattering function, which involves averaging over the cell population, hides the complexity of the collective movement. Using the t-distributed stochastic neighbor embedding (t-SNE), a popular unsupervised machine learning dimensionality reduction technique, we show that the phase space structure of an evolving colony of cells, driven by cell division and apoptosis, partitions into nearly disjoint sets composed principally of the core and periphery cells. The non-equilibrium phase separation is driven by the differences in the persistence of self-generated active forces induced by cell division. Extensive heterogeneity revealed by t-SNE paves the way toward understanding the origins of intratumor heterogeneity using experimental imaging data.
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