Abstract
Drug/cyclodextrin complexes self-assemble in aqueous solutions to form nanosized aggregates or nanoparticles. These complex aggregates are responsible for many of the physicochemical and biological properties of cyclodextrin complexes. Due to the aggregate formation aqueous drug/cyclodextrin solutions can behave more like dispersed nanoscale systems, such as nano-suspensions and liposomes, rather than true solutions. The aggregation can result in enhanced cyclodextrin solubilization of poorly soluble lipophilic drugs; they can serve as building blocks for ternary or higher order complexes; they can be developed into nano- and microparticulated drug carriers for targeted drug delivery to, for example, hair follicles; they can be developed into sustained drug delivery systems; and they can possible be used as mucus-penetrating drug delivery vectors. All of this can be obtained without chemical modifications of the cyclodextrin monomers.
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