Abstract
<p class="Els-Abstract-text">Wilt desease of banana caused by <em>Fusarium oxysporum</em> f.sp. <em>cubense</em> (FOC) is one of the most destructive deseases of banana in the tropics. Actinomycetes are the most economically and biotechnologically valuable prokaryotes able to produce wide range of bioactive secondary metabolites. The aims of the present study are to isolate and screen the actinomycetes with high potential ability to produce secondary metabolites that have inhibitory activity against plant pathogenic fungi, <em>Fusarium oxysporum</em> f. sp. <em>cubense</em>. Two isolates from Lampung and Cianjur showed activity against fungi. The isolates designed as L.3.1 and CiIA5b. The metabolites from potent stain was produced by extraction of culture filtrate with ethyl acetate : methanol (4:1), it was tested for their antifungal activity by well diffusion method. Evidence for in vitro antibiosis of L.3.1 and CiIA5b isolates was demonstrated by the zone of fungal-growth inhibition. Production of secondary metabolites was analysis by thin layer chromatography (TLC) and bioautography assays. In this study, the metabolites from L.3.1 and CiIA5b have showed good antifungal activity.</p><div><p class="Els-keywords"><em> </em></p><p class="Els-keywords"><strong>Keywords:</strong> Actinomycetes; antifungal activity; bioautography; secondary metabolites; thin layer chromatography.</p></div>
Highlights
Fungal phytopathogens are the cause of many plant diseases and much loss of crop yields, especially in subtropical and tropical regions [1]
Wilt desease of banana caused by Fusarium oxysporum f.sp. cubense (FOC) is one of the most destructive deseases of banana in the tropics [2]
The results indicated that L.3.1 and CiIA5b release an extra diffusible metabolite that inhibit hyphal growth of Fusarium oxysporum f. sp. cubense
Summary
Fungal phytopathogens are the cause of many plant diseases and much loss of crop yields, especially in subtropical and tropical regions [1]. Wilt desease of banana caused by Fusarium oxysporum f.sp. Cubense (FOC) is one of the most destructive deseases of banana in the tropics [2]. Microorganisms are biological control agents have high potential to control plant pathogens and no effect on the environment. Actinomycetes are the most economically and biotechnologically valuable prokaryotes able to produce wide range of bioactive secondary metabolites, such as antibiotics, antitumor agents, immunosuppressive agents and enzymes. These metabolites are known to posses antibacterial, antifungal, neuritogenic, anticancer, antialgal, antimalarial and anti-inflammatory activities [6]. Around 23 000 bioactive secondary metabolites produced by microorganisms have been reported and over 10 000 of these
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