Abstract
The crude ethanol extract of DodonaeaviscosaLinn (Sapindaceae) was partitioned into chloroform, aqueous, ethyl acetate, methanoland n-hexane soluble fractions. The extract and five fractions were tested against the larvae of Artemiasaline[Brine Shrimp Lethality Test (BST)]. The aqueous and methanol extracts were found to exhibited remarkable toxicity on brine shrimp larva at LC50value of 0.1326 and 62.5 μg/ml, while no activity recorded in the ethanol, chloroform, ethyl acetate, and n-hexane fractions LC50value >1000 μg/ml. The crude ethanol extract and five solvent fractions were tested for antimicrobial activity using agar diffusion method and the results revealed the zone of inhibition 15.0 mm at 10,000μg/ml was exhibited by the aqueous soluble fraction of the leaves of Dodonaeaviscosaagainst S. typhi. Meanwhile, methanol and ethanol fractions of Dodonaeaviscosaexhibited zone of growth inhibition 15mm and 30mm against S. aureus, at 10,000μg/ml.
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