Abstract
Aim of the study is to develop the diagnostic checklist based on the incidence and significance analysis of the external features of the dysplasia of the connective tissue (DCT) for its screening and assessment of its prevalence in the adolescents’ population. Materials and methods .110 adolescents (aged from 10 to 14 years) were examined, 81 of them had the dysplasia of the connective tissue (the first group). The second group was presented by 29 adolescents without DCT. The presence and degree of manifestation of DCT were established according to the criterions of Kadurina T. I., Gorbunova V.N. (2009), Т. Milkovska–Dimitrova (1987). There were the physical, laboratory and instrumental examination. Statistical processing of the results was carried out using Statistica 6.0 program and IBM SPSS Statistics 20.0. The diagnostic efficiency of the developed checklist was appreciated by means of the receiver operating characteristic curve (ROC curve). Results . The frequent occurrence of the DCT’s external features in adolescents was identified. The diagnostic checklist was developed. It was consisted of 12 items with illustrations, allowing readily identification of the dysplastic phenotype presence with diagnostic sensitivity 81.5% and specificity 79.3%. This checklist can be recommended as for the population studies, as for screening about DCT in adolescents during the primary outpatient pediatrician attendance. In the positive result of the screening it is necessary the further checkup to detect the organ changes and diagnosis updating.
Highlights
Aim of the study is to develop the diagnostic checklist based on the incidence and significance analysis of the external features of the dysplasia of the connective tissue (DCT) for its screening and assessment of its prevalence in the adolescents’ population
Materials and methods.110 adolescents were examined, 81 of them had the dysplasia of the connective tissue
The second group was presented by 29 adolescents without DCT
Summary
На основании анализа встречаемости и значимости внешних признаков дисплазии соединительной ткани разработать диагностический вопросник для скрининга дисплазии соединительной ткани и оценки ее распространенности в популяции подростков. Обследовано 110 подростков в возрасте 10–14 лет, из них 81 – с дисплазией соединительной ткани (ДСТ) (первая группа). Дисплазии соединительной ткани (ДСТ) посвящен ряд научных работ, что связано прежде всего как с ее высокой распространенностью, так и со значительным риском развития полиорганной патологии [1, 2, 3, 4]. Вместе с тем на практике существует некоторая неопределенность в оценке отдельных проявлений нарушений соединительной ткани, а часть из них оспаривается как маркеры ДСТ (в частности гипермобильность суставов, плоскостопие, сколиоз) [10]. Целью данного исследования – на основании анализа встречаемости и значимости внешних признаков ДСТ разработать диагностический вопросник для скрининга дисплазии соединительной ткани и оценки ее распространенности в популяции подростков
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