Abstract
The tribal people of Chhattisgarh state of India use Ficus glomerata for the treatment of diabetes therefore we planned to investigate antidiabetic effect of bark and root extract of bark and root in Streptozotocin (STZ)-induced diabetic rats. Oral administration of ethanol extract of bark and root of Ficus glomerata at the doses of 200 and 400 mg/kg body weight was studied in STZ-induced diabetic rats. After administration of extract the fasting blood glucose levels were significantly decreased. The oral glucose tolerance was also improved. The effect of extracts on serum lipid profile like total cholesterol, triglycerides, low density lipoprotein (LDL) and high density lipoprotein (HDL) were also measured in the diabetic and non diabetic rats. There was significant reduction in total cholesterol, LDL and improvement in HDL in diabetic rats were observed. The activity of the plant extracts was comparable with glibenclamide, a well-known antidiabetic drug. These results indicated that Ficus glomerata possesses significant antidiabetic and antihyperlipidemic effect.
Highlights
Medicinal plants continue to provide valuable therapeutic agents, both in modern and in traditional medicine
Non-insulin dependent diabetes mellitus was induced[7,8] in overnight fasted adult Wistar strain albino male rats weighing 170 – 220 g by a single intraperitoneal injection of 60 mg/kg Streptozotocin, 15 extracts of Ficus glomerata, there was a significant reduction in plasma glucose level, while in glucose control rats the plasma glucose level increased
Ethanol extract of Ficus glomerata of bark (EFGB), Ethanol extract of Ficus glomerata of root (EFGR), Values are expressed as mean ± SEM (Number of animals, n=6); significantly different at aP
Summary
Medicinal plants continue to provide valuable therapeutic agents, both in modern and in traditional medicine. Most of the hypoglycemic agents used in allopathic medicines are reported to have side effects in the long run. The uses of herbal medicines in management of diabetes are exhibiting more beneficial than allopathic drugs, due to its safe and cost effective[2]. Ficus glomerata belongs to the family Moraceae (Mulberry family), and is commonly known as Gular, Umar, Umber, and Udumbara. It is an herb found all parts of India. Plant is commonly used in antihyperlipidemic, diabetic, hepatoprotective, analgesic and wound healing[4,5]. 2 Materials and Methods minutes after i.p. administration of 120 mg/kg of nicotinamide
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