Evaluation of Antidiabetic Activity of Ethanol Extracts of Leaves and Barks of Alangium salvifolium in Streptozotocin-Induced Diabetic Rats

Abstract

Alangium salvifolium is a medicinal plant, used by herbalist for treating various diseases, one of which is diabetes mellitus in Central India. However, its antidiabetic activity has not been scientifically validated so far. The aim of the present study was to evaluate the antidiabetic activity of ethanol extracts of leaves and barks of Alangium salvifolium against strepozotocin (STZ)-induced diabetic rats. The ethanol extracts of leaves and barks of Alangium salvifolium at doses of 200 and 400 mg/kg body weight was administered orally to diabetic rats. The blood glucose levels were monitored at specific intervals and found significantly lowered the blood glucose level. Glibenclamide was used as a standard drug at a dose of 0.25 mg/kg. The effect of extracts on induced hyperlipidemia was analyzed where the extracts significantly lowered the elevated total cholesterol, triglycerides (TGL) and low density lipoprotein (LDL) level while increased the high density lipoprotein (HDL). Moreover, the decreased in body weight of rats after induction of diabetes, and increased in body weight of rats after treatment with extracts was observed. The experimental data exhibited that extract of leaves and barks of Alangium salvifolium has significant antidiabetic activity in streptozotocin-induced rats compared to standard drug. The ethanol extracts of leaves exhibited maximum antidiabetic activity as compared to barks extract.