Abstract
Problem statement: The present study was aimed to explore the hypoglycemic and hypolipidemic activity of Nyctanthes arbortristis linn roots against Streptozotocin (STZ) induced experimental rats. Approach: Ethanolic extract of roots of Nyctanthes arbortristis was administered to streptozotocin induced rats.Glibenclamide was used as a standard drug. Blood glucose levels were determined after oral administration of a dose of Nyctanthes arbortristis (200 mg kg-1 b.wt) in diabetic groups. Blood glucose levels were determined on 0, 7th, 14th, 21st and 28th day after oral administration of ethanolic extracts of Nyctanthes arbortristis (200 mg kg-1). Results: An ethanolic extract of Nyctanthes arbortristis was found to reduce blood sugar in streptozotocin induced diabetic rats. Reduction in blood sugar could be seen from 7th day after continuous administration of the extract. The effect of extracts of Nyctanthes arbortristis on serum lipid profile like Total Cholesterol, triglycerides, low density, very low density and high density lipoprotein were also measured in the diabetic and non diabetic rats. There was significant reduction in Total Cholesterol, LDL cholesterol, VLDL cholesterol and improvement in HDL cholesterol in diabetic rats. Conclusion: We concluded that Nyctanthes arbortristis possesses a hypoglycemic and hypolipidemic effect.
Highlights
Diabetes mellitus is a complex disorder that characterized by hyperglycemia resulting from malfunction in insulin secretion and/or insulin action both causing by impaired metabolism of glucose, lipids and protein (Scheen, 1997)
In animals treated with streptozotocin (50 mg kg−1 i.p) (Group II), a significant increase in serum glucose level was observed on 7th, 14th, 21st and 28th day when compared with normal rats (Group I)
Standard Glibenclamide (Group III) lipoproteins pattern in diabetes mellitus due to the fact reduced triglycerides, Total Cholesterol, very Low Density Lipoproteins (VLDL), Low Density Lipoproteins (LDL) and increased High Density Lipoproteins (HDL) when compared with normal (Group I).The ethanolic extract showed significant decrease (p
Summary
Diabetes mellitus is a complex disorder that characterized by hyperglycemia resulting from malfunction in insulin secretion and/or insulin action both causing by impaired metabolism of glucose, lipids and protein (Scheen, 1997). Toxicity studies: In performing preliminary test for pharmacological activity in rats, ethanolic extract did In animals treated with streptozotocin (50 mg kg−1 i.p) (Group II), a significant increase in serum glucose level was observed on 7th, 14th, 21st and 28th day when compared with normal rats (Group I).
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
