Schizophrenia is associated with over-expression of the interleukin-2 receptor gamma gene

Abstract

Event Abstract Back to Event Schizophrenia is associated with over-expression of the interleukin-2 receptor gamma gene Hovsep Ghazaryan1, 2*, Anna Boyajyan1, Roksana Zakharyan1, Ani Melkonyan1, Zdenka Navratilova2, Petra Klevcova2 and Martin Petrek2 1 Institute of Molecular Biology, National Academy of Sciences of the Republic of Armenia, Armenia 2 Institute of Molecular and Translational Medicine, Faculty of Medicine and Dentistry, Palacky University, Czechia Altered immune response, including low-grade inflammatory processes, are involved in the pathogenesis of schizophrenia - a chronic neuropsychiatric disorder with complex etiology. Distinct gene variants and a number of regulatory, pro-inflammatory and chemotactic cytokines together with their receptors have been implicated in this disorder. Interleukin-2 receptor gamma (IL-2RG) represents a component of several cytokine receptors and so far, no data have been reported about this receptor in schizophrenia, including its functional state. The aim of this study was, therefore, to investigate mRNA expression of the IL2RG gene in schizophrenia patients in comparison with healthy control subjects. Total RNA was isolated from peripheral blood of 66 schizophrenia patients and 99 healthy subjects from Armenian population. The mRNA expression was determined by quantitative real-time polymerase chain reaction (RT-PCR) using PSMB2 as housekeeping gene. IL2RG mRNA expression was upregulated in peripheral blood of patients in comparison with controls (patients vs. controls, mean±SEM: 3.06±0.47 vs. 0.52±0.06, p<0.0001). In conclusion, our findings suggest that over-expression of the IL2RG gene may be implicated in altered immune response in schizophrenia and thus associated with pathomechanisms of this disorder. Further investigations are required to extend this observation and relate it to disease clinical phenotypes. Acknowledgements We thank the administration and medical staff of the clinics of Psychiatric and Erebouni Medical Centers of the Ministry of Health of the Republic of Armenia for selection of patients and healthy subjects. The study was supported by the International Visegrad fund scholarship (HG_51200594), NAS RA, IGA_PU_LF_2013_009, and CZ.1.05/2.1.00/01.0030 funds. Keywords: Schizophrenia, interleukin-2 receptor gamma, mRNA, cytokine, upregulation Conference: 15th International Congress of Immunology (ICI), Milan, Italy, 22 Aug - 27 Aug, 2013. Presentation Type: Abstract Topic: Immune-mediated disease pathogenesis Citation: Ghazaryan H, Boyajyan A, Zakharyan R, Melkonyan A, Navratilova Z, Klevcova P and Petrek M (2013). Schizophrenia is associated with over-expression of the interleukin-2 receptor gamma gene. Front. Immunol. Conference Abstract: 15th International Congress of Immunology (ICI). doi: 10.3389/conf.fimmu.2013.02.00380 Copyright: The abstracts in this collection have not been subject to any Frontiers peer review or checks, and are not endorsed by Frontiers. They are made available through the Frontiers publishing platform as a service to conference organizers and presenters. The copyright in the individual abstracts is owned by the author of each abstract or his/her employer unless otherwise stated. Each abstract, as well as the collection of abstracts, are published under a Creative Commons CC-BY 4.0 (attribution) licence (https://creativecommons.org/licenses/by/4.0/) and may thus be reproduced, translated, adapted and be the subject of derivative works provided the authors and Frontiers are attributed. For Frontiers’ terms and conditions please see https://www.frontiersin.org/legal/terms-and-conditions. Received: 21 Mar 2013; Published Online: 22 Aug 2013. * Correspondence: Mr. Hovsep Ghazaryan, Institute of Molecular Biology, National Academy of Sciences of the Republic of Armenia, Yerevan, Armenia, h_ghazaryan@mb.sci.am Login Required This action requires you to be registered with Frontiers and logged in. To register or login click here. Abstract Info Abstract The Authors in Frontiers Hovsep Ghazaryan Anna Boyajyan Roksana Zakharyan Ani Melkonyan Zdenka Navratilova Petra Klevcova Martin Petrek Google Hovsep Ghazaryan Anna Boyajyan Roksana Zakharyan Ani Melkonyan Zdenka Navratilova Petra Klevcova Martin Petrek Google Scholar Hovsep Ghazaryan Anna Boyajyan Roksana Zakharyan Ani Melkonyan Zdenka Navratilova Petra Klevcova Martin Petrek PubMed Hovsep Ghazaryan Anna Boyajyan Roksana Zakharyan Ani Melkonyan Zdenka Navratilova Petra Klevcova Martin Petrek Related Article in Frontiers Google Scholar PubMed Abstract Close Back to top Javascript is disabled. Please enable Javascript in your browser settings in order to see all the content on this page.