Abstract
Artificially performing chemical reactions in living biosystems to attain various physiological aims remains an intriguing but very challenging task. In this work, the Schiff base reaction was conducted in cells using Sc(OTf)3 as a catalyst, based on which the in situ synthesis of hollow covalent organic polymer (HCOP) was readily accomplished without external stimuli. The reversible Schiff base reaction-mediated intracellular Oswald ripening endows the HCOP with a woolen, spherical, hollow porous structure, and a large specific surface area. The intracellularly generated HCOP reduced cellular motility by restraining actin polymerization, which consequently induced mitochondrial deactivation, apoptosis, and necroptosis. The presented Schiff base reaction-inspired intracellular synthesis system has strong potential to regulate cell fate and biological functions, opening up a new strategic possibility for intervening cellular behavior.
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