Sarcomere generation is localized to intercalated disk and dependent on store operated Ca2+ entry in a model of rapid onset (Takotsubo) hypertrophy

Abstract

To achieve hypertrophic growth, a cardiac myocyte must incorporate new sarcomeres within the cell. The location and manner of this growth during either physiologic or pathologic hypertrophy is uncertain. Previous literature has shown sarcomeric growth occurring at the intercalated disk (ID) during developmental myocyte growth. However, there have not been any models describing sarcomere generation under hypertrophic conditions. Previously, we have shown a relationship between store operated calcium entry (SOCE) that occurs near IDs and hypertrophic processes.